Nanosecond laser treatment for age-related macular degeneration does not induce focal vision loss or new vessel growth in the retina

KA Vessey; T Ho; AI Jobling; SA Mills; MX Tran; A Brandli; J Lam; RH Guymer; EL Fletcher

Journal article

Nanosecond laser treatment for age-related macular degeneration does not induce focal vision loss or new vessel growth in the retina

KA Vessey, T Ho, AI Jobling, SA Mills, MX Tran, A Brandli, J Lam, RH Guymer, EL Fletcher

Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2018

DOI: 10.1167/iovs.17-23098

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Abstract

PURPOSE. Subthreshold, nanosecond pulsed laser treatment shows promise as a treatment for age-related macular degeneration (AMD); however, the safety profile needs to be robustly examined. The aim of this study was to investigate the effects of laser treatment in humans and mice. METHODS. Patients with AMD were treated with nanosecond pulsed laser at subthreshold (no visible retinal effect) energy doses (0.15-0.45 mJ) and retinal sensitivity was assessed with microperimetry. Adult C57BL6J mice were treated at subthreshold (0.065 mJ) and suprathreshold (photoreceptor loss, 0.5 mJ) energy settings. The retinal and vascular responses were analyzed by fundus imaging, histologic assessment, and q..

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University of Melbourne Researchers

Kirstan Vessey Author

Andrew Jobling Author

Alice Brandli Author

Robyn Guymer Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Supported by No. LP150100482 (ARC Linkage to ELF), No. 1061418, No. 1138253 (National Health & Medical Research Council of Australia [NH & MRC] Project Grant to ELF); NH & MRC Fellowship GNT1103013 (RHG).